A mild catalytic system for radical conjugate addition of nitrogen heterocycles.
نویسندگان
چکیده
The direct addition of pyridine and diazine units to electron-poor alkenes has been achieved via a redox radical mechanism that is enabled by limiting the effective concentration of the hydrogen-atom source. The described method is tolerant of acidic functional groups and is generally applicable to the union of a wide range of Michael acceptors and 6-membered heterocyclic halides.
منابع مشابه
A mild catalytic system for radical conjugate addition of nitrogen heterocycles† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc00243b Click here for additional data file.
Pyridines and diazines are critical structural elements in many biologically active small molecules and, as a result, signicant research effort has been devoted to their preparation. In addition to de novo heterocycle assembly, a number of powerful methods exist for the functionalization of these heteroarenes. For example, Minisci radical addition is a direct and effective synthetic approach t...
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عنوان ژورنال:
- Chemical science
دوره 8 4 شماره
صفحات -
تاریخ انتشار 2017